ea0019s72 | Young Endocrinologist prize lecture | SFEBES2009
Papacleovoulou G
, Critchley H
, Hillier S
, Mason I
Based on the hypothesis that incessant ovulation and ovulation-related inflammation are associated with the development of epithelial ovarian cancer, we have investigated in vitro the role of androgen and progesterone pre-receptor metabolism and steroid receptor signalling in human ovarian surface epithelium (hOSE) wound healing. Ovulation-associated injury was mimicked with exposure of primary hOSE cells to interleukin-1α, whereas post-ovul...